Studies

Studies and publications

Open studies

First-Line Study for Advanced Colorectal Cancer with MSI and/or dMMR

Therapeutic area: Oncology — Colorectal Cancer

A clinical study comparing a targeted therapy combined with immunotherapy against immunotherapy alone as initial treatment for advanced or metastatic colorectal adenocarcinoma. It is intended for people whose tumors have microsatellite instability (MSI) and/or mismatch repair deficiency (dMMR).

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Recruiting

Study for HR+/HER2– Metastatic Breast Cancer with a PIK3CA Mutation

Therapeutic area: Oncology — Breast Cancer

A clinical study evaluating a targeted therapy combined with hormonal treatment for people with hormone receptor-positive (HR+), HER2-negative metastatic breast cancer and a PIK3CA mutation whose disease has progressed after treatment with a CDK4/6 inhibitor. The study compares two doses of the targeted therapy.

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Recruiting

First-Line Study for Advanced Lung Cancer with a KRAS G12C Mutation

Therapeutic area: Oncology — Lung Cancer

A clinical study evaluating combination treatments as first-line therapy for people with advanced or metastatic non-small cell lung cancer and a KRAS G12C mutation. The treatments being studied include targeted therapy and immunotherapy, with or without chemotherapy, depending on the tumor’s characteristics.

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Recruiting

First-Line Study for Metastatic Non-Small Cell Lung Cancer

Therapeutic area: Oncology — Lung Cancer

A clinical study comparing two immunotherapy options as initial treatment for people with metastatic non-small cell lung cancer and high PD-L1 expression. The study aims to evaluate the efficacy and safety of the treatments being studied.

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Closed studies

There are currently no published studies in this category. Check back soon or contact us to learn about protocols in development.

Published studies

Finished

Long-term outcome after percutaneous endoscopic gastrostomy in geriatric Mexican patients

Therapeutic area: Geriatrics and clinical nutrition

A retrospective cohort study of 110 Mexican patients aged over 70 years who underwent percutaneous endoscopic gastrostomy between January 2005 and December 2012. The study evaluated long-term survival and prognostic factors associated with mortality. Karnofsky performance status, the Charlson Comorbidity Index and postoperative hypoalbuminemia were identified as independent risk factors. The findings highlight the relevance of nutritional and functional status in the assessment of these patients.

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Finished

Associations Prevalence of high-grade cervical intraepithelial neoplasia in Mexican women aged under 40 yearsetween domestic violence and psychosomatic symptoms and health behaviors during pregnancy and the puerperium

Therapeutic area: Women’s Health and Obstetrics

Observational study conducted in 359 Mexican women under 40 years of age to determine the prevalence of high-grade squamous intraepithelial cervical lesions and assess associated factors. High-grade lesions were identified in 39% of participants, with the highest proportion among women aged 35–39 years. The study also found a high prevalence of human papillomavirus infection and confirmed its association with high-grade cervical lesions.

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Finished

Carcinoid heart syndrome: a problem that deserves recognition. A case report

Therapeutic area: Oncology and Cardio-Oncology

Case report of a 54-year-old woman with metastatic neuroendocrine carcinoma who subsequently developed carcinoid heart syndrome. The condition resulted in severe pulmonary and tricuspid valve regurgitation and required multidisciplinary management including systemic therapy, tricuspid valve replacement, and chemoembolization of liver metastases. The case highlights the importance of timely recognition of cardiovascular complications associated with neuroendocrine tumors.

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Finished

OncoloA decade of hair-loss clinical trials: a registry-based analysis of studies registered on ClinicalTrials.govgía quirúrgica

Therapeutic area: Dermatology and Trichology

Clinical research study analyzing 514 hair-loss trials registered on ClinicalTrials.gov between 2015 and 2025. The study evaluated trends in alopecia research, including the conditions investigated, treatment modalities, geographic distribution, outcome assessment methods, and sponsorship. The findings showed rapid growth in hair-loss research, particularly after 2020, while identifying important geographic disparities and variability in outcome assessment.

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Finished

Associations between domestic violence and psychosomatic symptoms and health behaviors during pregnancy and the puerperium

Therapeutic area: Women’s Health and Obstetrics

Observational study conducted in 400 women during the immediate postpartum period to evaluate the relationship between domestic violence, mental health, risk behaviors, and perinatal outcomes. A total of 31.5% screened positive for violence, primarily psychological and economic. Exposure to violence was associated with higher odds of postpartum depression and tobacco use, highlighting the importance of identifying vulnerability factors during pregnancy and the puerperium.

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Process

How we manage each protocol

01Receipt of protocol opportunity
02Feasibility assessment
03Identification of potential population
04Selection of investigator and clinical team
05Site activation
06Patient recruitment
07Study visit follow-up
08Protocol closure and documentation